Allera Health Products markets this product using the names Immune Extra and ImmunExtra - NPN: 80056907.
The Proligna in ImmunExtra is a patented extract of Scotch pine cones, whose medicinal benefits were recognized by the ancient Greeks and contemporary Japanese, and have been the subjects of intense research, which has found that not only can it reduce the levels of IgE (the immune molecule associated with triggering an allergic response) among those with allergies, but it can also dramatically increase the production of mature dendritic immune cells -- the type which learns the difference between true pathogens versus harmless allergens or even the body's own cells, and which marshal the activities of the immune system's Th2 (allergy/asthma) and Th1 (specific disease fighting) responses, accordingly.
Abe M, Okamoto K, Konno K, Sakagami H. "Induction of antiparasite activity by pine cone lignin-related substances." In Vivo, 1989; 3(6):359-62.
Bradley WG, Widen RH, Weiser AM, Powers JJ, Fountain LB, Punjwani P, Lofgren SM, Hadzic T, Klein R, Green WH, Tanaka A. "The novel differentiation of human blood mononuclear cells into CD1a-negative dendritic cells is stimulated in the absence of exogenous cytokines by an extract prepared from pinecones." International Immunopharmacology 2003 Feb; 3(2):209-23.
Burrows M, Assundani D, Celis E, Tufaro F, Tanaka A, Bradley WG. "Oral administration of PPC enhances antigen-specific CD8+ T cell responses while reducing IgE levels in sensitized mice." BMC Complement Altern Med. 2009 Nov 30; 9:49. doi:10.1186/1472-6882-9-49
Sakagami H, Kawazoe Y, Komatsu N, Simpson A, Nonoyama M, Konno K, Yoshida T, Kuroiwa Y, Tanuma S. "Antitumor, antiviral and immunopotentiating activities of pine cone extracts: potential medicinal efficacy of natural and synthetic lignin-related materials (review)." Anticancer Res, 1991; 11(2):881-8.
Sakagami H, Konno K, Kawazoe Y, Lai P, Nonoyama M. "Multiple immunological functions of extracts from the cone of Japanese white pine, Pinus parviflora Sieb. et Zucc." Adv Exp Med Biol., 1992; 319:331-5.
Sakagami H, Yoshihara M, Fujimaki M, Wada C, Komatsu N, Nakashima H, Murakami T, Yamamoto N. "Effect of pine seed shell extract on microbial and viral infection." In Vivo, 1992; 6(1):13-6.