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Alterra -  MGN-3 Bio-Bran

Alterra - MGN-3 Bio-Bran

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Info: 50 Vegetable Capsules - 650 mg

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MGN3 Bio-Bran combines Astragalus, an ancient herb from Traditional Chinese Medicine used to promote overall vitality and combat chronic illness and debility, with a more recent entry to the herbal immune support domain: RBAC, an extract from Rice Bran, which now has over 20 years of clinical studies behind it.

Product Notes:

Now more than ever, people are seeking a way to shore up their immune system. Astragalus has been used for many centuries in TCM (where it's known as Huangqi or Huang Qi) to stimulate the immune system and strengthen the body against disease, and more recently, as an adjunct to other types of therapies.

In the West, it is mainly used to stave off upper respiratory tract infections or colds and flus in particular, since some studies have indicated it has antiviral properties.

RBAC stands for Rice Bran Arabinoxylan Compound. Arabinoxylan is a kind of cellulose found in the outer shell of certain cereal grains like rice (which can then be extracted and concentrated with the help of enzymes derived from mushrooms). It's a dietary fibre, which not only serves as a prebiotic (it fosters the growth of probiotic bacteria, which can help improve digestion and immune function), but also contains two types of sugar (arabinose and xylose) believed to have antioxidant properties.

Arabinoxylan also contains a whole range of other bioactive phytochemicals (such as β-sitosterol, γ-oryzanol, ferulic acid, tocotrienols or tocopherols, tricin, and phytic acid) which collectively protect against tissue damage by scavenging free radicals, blocking chronic inflammatory responses, and activating anticancer immune responses.

Studies indicate some of its specific immunomodulating effects include tripling the activity of T-cells, B-cells, and NK (natural killer) cells; increasing TNF (Tumor necrosis factor)-Alpha levels (which promotes inflammatory responses to combat bacterial infections like pneumonia), and helping dendritic cells mature, so they can initiate antigen-specific immune responses.

Naming Notes:

This product may also have been marketed with these alternative names under the Herbasanté or Alterra brands in Canada - MGN-3 Forte; Immune-NK; MGN-3 Plus; and MGN-3 XS. The RBAC component of it is also sold as either a functional food or a nutritional supplement under a number of different brand names in various parts of the world, such as BRM4 in the USA; Biobran or Ribraxx in Australia; Biobran MGN-3 in Japan, or Lentin Plus in other parts of Asia.

More: See rice bran solubles and The Health Benefits of Rice Bran Solubles & Plant Sterols.

MGN-3 Bio-Bran Ingredients:

Each capsule contains:

Rice Bran Arabinoxylan Compound (RBAC): 500 mg
Astragalus membranaceus extract (5:1 DHE: 750mg): 150 mg

Other ingredients: Microcrystalline cellulose.

Suggested Usage:

Step 1: Take 2 capsules, 3 times per day for 4 weeks before or after a meal.

Step 2: After 4 weeks, reduce dosage to the maintenance level of 2 capsules daily.


For adult use only. Do not use Alterra Herbasante MGN3 Bio-Bran if you are pregnant or breastfeeding and/or if you are taking immune system suppressors.

Health Canada Natural Product Number: 80030184.

Supporting Science:

Auyeung, Kathy K et al. “Astragalus membranaceus: A Review of its Protection Against Inflammation and Gastrointestinal Cancers.” The American Journal of Chinese Medicine, 2016.

Chen, Zhejie et al. “Astragali Radix (Huangqi): A promising edible immunomodulatory herbal medicine.” Journal of Ethnopharmacology, Aug. 2020.

Elsaid, A F et al. “The enhancing effects of Biobran/MGN-3, an arabinoxylan rice bran, on healthy old adults' health-related quality of life: a randomized, double-blind, placebo-controlled clinical trial.” Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, Feb. 2020.

Elsaid, Ahmed F et al. “Dietary Supplementation with Biobran/MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial.” Nutrients, Nov. 2021.

Lewis, John E et al. “The Novel Effects of a Hydrolyzed Polysaccharide Dietary Supplement on Immune, Hepatic, and Renal Function in Adults with HIV in a Randomized, Double-Blind, Placebo-Control Trial.” Journal of Dietary Supplements, May 2020.

Li, Shanshan et al. “Anti-tumor effects and mechanisms of Astragalus membranaceus (AM) and its specific immunopotentiation: Status and prospect.” Journal of Ethnopharmacology, Aug. 2020.

Liu, Qian et al. “Rice bran polysaccharides and oligosaccharides modified by Grifola frondosa fermentation: Antioxidant activities and effects on the production of NO.” Food Chemistry, May 2017.

Ooi, Soo Liang et al. “The Health-Promoting Properties and Clinical Applications of Rice Bran Arabinoxylan Modified with Shiitake Mushroom Enzyme - A Narrative Review.” Molecules (Basel, Switzerland), April 2021.

Ooi, Soo Liang et al. “Evidence-Based Review of BioBran/MGN-3 Arabinoxylan Compound as a Complementary Therapy for Conventional Cancer Treatment.” Integrative Cancer Therapies, July 2018.

UPC / Barcode: 625744895004