NMN + Wheat Germ: Supporting Healthy Aging & Cellular Longevity
Video Transcription (AOR) - Healthy Cells for a Long Life
Every cell in our body is like a little ecosystem - a community with varying structural landscapes, communication networks, and activity centres. The instructions for how these cells function in response to the environment will depend on genetic messages transcribed from DNA stored in the nucleus of the cells.
One very important activity centre is the mitochondria, known as the powerhouse of the cell. Producing energy is hard work and metabolic activity creates reactive oxygen species which can be harmful to the mitochondria. Think of this as smoke building up in a kitchen without proper ventilation over time. This can damage cellular structures and cause loss of function, referred to as oxidative stress.
To avoid this, we have evolved multiple signals which can set off chain reactions to correct, stop, or reverse this damage. One of these critical intermediaries is called NAD+ (nicotinamide adenine dinucleotide). This critical coenzyme is found in every cell in the body which means it will initiate or assist in hundreds of metabolic reactions.
Specifically, NAD+ regulates energy creation and utilization. It helps the movement of electrons and hydrogen ions between enzymes and is key in signaling the molecule that helps communication between different organ systems.
The amount of NAD+ compared to the NADH will also trigger a number of genetic changes, activating genes to increase or decrease energy production, storage, and cellular repair. The NAD+ to NADH ratio is essential to the creation of energy in the body and the regulation of pivotal cellular processes.
Researchers have seen that with lower NAD+ levels the enzymes either work inefficiently or not at all. Unfortunately, like many other key molecules in the body, NAD+ levels also decline with age. The decline in NAD+ levels is seen alongside a loss in the function of our cells. This means that their ability to make cell energy becomes less effective while their ability to protect against cell damage goes down.
Cells become more susceptible to damage from things you expose your body to including foods and beverages, environmental pollutants, UV damage, inflammation, infections, and chronic stress. The cumulative effect can mean an accelerated shortening of DNA due to uninhibited replication and other cell cycle abnormalities.
Activation of cellular senescence or deterioration can cause premature cell death as well as the accumulation of inflammatory markers and free radicals. You are more susceptible to metabolic disorders like type 2 diabetes, cardiovascular diseases, and neurodegenerative diseases.
While aging is something that all humans experience, there are ways to slow cellular damage and dysfunction associated with aging. Boosting NAD+ is a sensible approach, with one option being a B vitamin derivative.
NMN is a downstream product of vitamin B3 that's also a direct precursor to NAD+. It's water soluble, stable in liquids, and has good bioavailability and absorption. It's also detectable within 30 minutes of ingestion, making NMN the NAD+ boosting molecule of choice.
Over the last 20 years, there have been tremendous advancements in our understanding of these genetic alterations. Some of the more well-understood gene activation pathways include the activation of sirtuin, AMPK, and clock genes.
Compounds and various natural products and lifestyle changes have been studied to see how genes are activated. One of the most discussed ways to improve cellular longevity and health span is targeted caloric restriction. Certain molecules have been shown to activate the same pathways that we see activated with caloric restriction.
Reducing reactive oxygenated species has also proven to be effective. This involves adding antioxidants as they are powerful cellular cleansers that neutralize and stabilize the toxic byproducts of normal cellular energy production.
Lastly is autophagy, which is the cellular recycling of worn-out, dead, and dysfunctional organelles and molecules within the cell. Think of it as removing the garbage from your home daily to avoid issues like odor, decay, clutter, and the potential for generating and spreading disease. By ensuring autophagy is occurring in cells, we can keep them clear and healthy over more replication cycles.
NMN supplementation as an NAD precursor has been shown to enhance energy, metabolism, suppress age-associated weight gain, and improve insulin sensitivity, eye function, and mitochondrial metabolism. It has also been linked to age prevention, improving cardiovascular health, reduced inflammation, and enhanced cognitive function.
Spermidine is derived from wheat germ and belongs to a class of molecules called polyamines. Polyamines are positively charged molecules similar to NAD+ and are important in stabilizing bulky negatively charged molecules like RNA, DNA, and proteins. They keep them stable and free from attack by stressors and are important for cell growth, cell repair, and inducing autophagy.
Supplementing with spermodyne has been shown to have healthy aging effects by improving the health of cells and prolonging their lifespan. AOR has found an Innovative and novel approach to promote cellular health and improve the experience of aging with NMN plus wheat germ. It's recommended to take 100 milligrams of NMN per day and one milligram of spermadine per day.
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