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Douglas Laboratories - TMC (Tri-Metabolic Control)

Douglas Laboratories - TMC (Tri-Metabolic Control)

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Info: 120 Vegetarian Capsules

TMC is currently unavailable from the manufacturer.

TMC combines LOWAT, which features clinically studied extracts of the Piper betle leaf and Dolichos biflorus seed, with equal measures of acetyl-L-carnitine. These three antioxidants can help protect against the oxidative damage which may be disrupting metabolic activity and cell structure.

Product Notes:

Tri-Metabolic Control

The ingredients in TMC have been selected to support three metabolic hormones which play an important role in brain function and appetite control: ghrelin, an appetite-stimulating hormone; leptin, the hormone that signals the brain that we're full; and adiponectin, which modulates several metabolic processes, including glucose regulation and fatty acid oxidation.

TMC was formulated by Dr. Penny Kendall-Reed, a nationally-recognized naturopath specializing in metabolic and neuro-endocrine health, to help control appetite, satiety, and fat metabolism as part of a healthy weight management program. (She is featured in the presentation below, and discusses this formulation in particular about two-thirds of the way in, at the 42:40 minute mark.)

TMC combines LOWAT with Acetyl-L-carnitine. LOWAT is a patent-pending compound that consists of two ingredients which have been traditionally used in Indian culture, and has been evaluated in a randomized, double-blind, placebo-controlled clinical study.

Acetyl-L-carnitine is found in foods of animal origin, and can have membrane protective properties by scavenging the harmful superoxide radicals which may be damaging membrane lipids.


Each TMC capsule contains:

Acetyl-L-Carnitine [(2R)-2-(Acetyloxy)-3-carboxy-N,N,N-trimethyl-1-propanaminium inner salt]: 150 mg
LOWAT®: 150 mg, which consists of:
- Catjang (Dolichos biflorus), seed [Vigna unguiculata subsp. cylindrica, 12:1, DHE: 1080 mg Dry]: 90 mg
- Piper betle, leaf (7:1, DHE: 420 mg Dry): 60 mg

Non-medicinal ingredients: Hydroxypropyl methylcellulose (capsule), cellulose, silica, and ascorbyl palmitate.

Suggested Usage:

Adults: Take 2 capsules 30 minutes before a meal, 2 to 3 times daily, or as directed by a healthcare professional. Store in a cool, dry place, away from direct light.


Keep out of reach of children. Do not use Douglas Labs TMC if you are pregnant or if you are trying to conceive. Consult a healthcare practitioner prior to use if you are breastfeeding, or if you have liver disease, kidney disease and/or a seizure disorder. May cause digestive problems.

Health Canada Natural Product Number: 80076486.

Supporting Science:

"Efficacy of a Natural Weight Management Herbal Formulation in Obese Human Subjects." Paper presented at: American College of Nutrition 51st Annual Meeting, New York, NY Oct 7-9, 2010.

"Efficacy of an herbal formulation LI10903F containing Dolichos biflorus and Piper betle extracts on weight management." Lipids in Health and Disease. 2012.

"Clinical evidence of the effects of carnitine supplementation on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: a systematic review and meta-analysis." Gynecological Endocrinology, 2022.

"Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis." Clinical Nutrition ESPEN, 2020.

UPC / Barcode: 310539978047