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Genestra - Neurogen Cognition

Genestra - Neurogen Cognition

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Info: 60 Veg. Capsules

Neurogen Cognition is one of several "Neurogen" or "Neuro" themed products from Genestra formulated to provide neuroregenerative support for the brain. It combines standardized extracts of three types of herbs (two of them in special proprietary forms) backed by scientific research for improving and/or protecting certain aspects of memory, cognitive health and brain function.

Info: 60 Veg. Capsules

Neurogen Cognition is one of several "Neurogen" or "Neuro" themed products from Genestra formulated to provide neuroregenerative support for the brain. It combines standardized extracts of three types of herbs (two of them in special proprietary forms) backed by scientific research for improving and/or protecting certain aspects of memory, cognitive health and brain function.

Product Notes:

As we age, we tend to lose a step, not only in our physical capacities but also our cognitive functions. And just as we can take certain supplements such as protein powders, collagen or calcium to combat the loss of muscle mass or bone density, other supplements may be able to help optimize our existing mental faculties and slow down the progression of neurodegenerative diseases. Neurogen Cognition was specifically developed to do that (to support cognitive health and brain function), with premium forms of three types of herbal extracts supported by recent scientific research: Bacopa, Curcumin, and Ginger.

Bacopa (also known as Brahmi) may still be relatively unknown in North America, but it's a plant that's been used in traditional Ayurvedic medicine for a variety of purposes for millennia (including memory enhancement). Over the past 20 years or so, numerous randomized, placebo-controlled trials have shown bacopa can improve memory and attention. That's bolstered by other research suggesting the likely mechanisms for those effects are due to its antioxidant properties and abilities to help increase cerebral blood flow and regulate neurotransmitter levels. Genestra has selected a proprietary form of a clean, standardized extract of bacopa here, called BACOGNIZE™. Clinical research has demonstrated it can improve cognitive function in both healthy students and older adults (enhancing their performance in a test measuring attention, freedom from distractibility, and working memory), and it's also been shown to help reduce fatigue and improve the psychological effects of stress on mood.

The second major ingredient is Curcumin, which of course is derived from the spice Turmeric, and is another long-standing Ayurvedic medicine backed by plenty of contemporary research. Curcumin is well-known to be able to help reduce inflammation and is widely used in supplements to relieve joint pain and improve mobility, but it turns out that inflammation may be a risk factor for impaired reasoning and memory, as well. Moreover, curcumin may also be able to help boost BDNF (brain-derived neurotrophic factor), a protein that helps regulate the structure, function, and development of the brain's neurons and synapses and helps neurons grow and form new connections. Here, Genestra has turned to another proprietary type: LONGVIDA™ Optimized Curcumin, which is produced by encapsulating the free curcumin in a matrix of three types of fatty acids to enhance its solubility and enable it to survive digestion and enter the bloodstream to reach the target tissues, such that it is over 100 times more bioavailable than just regular curcumin. Clinical research has demonstrated LONGVIDA can help improve cognitive functions such as sustained attention and working memory tasks and reduce the fatigue and anxious or foul mood that can be induced by the stress associated with having to carry out cognitively demanding tasks.

Rounding out the trio is Ginger, another important plant with antioxidant properties that's long been used in herbal medicine to reduce inflammation (and of course nausea). As with curcumin, studies indicate ginger can inhibit inflammatory responses that occur in the brain, and it is both being actively studied and used in some places to help with variety of neuro-degenerative diseases. (NDDs: chronic neurological disorders associated with cognitive or motor dysfunction, such as Alzheimer's disease.) Daily doses of ginger extract have even been shown to improve reaction time and working memory in healthy people (in a 2012 study of middle-aged women).

Neurogen Cognition Ingredients:

Each capsule contains:

200 mg LONGVIDATM Optimized Curcumin, providing:
- Curcumin (from Curcuma longa rhizome): 40 mg

150 mg Bacognize™ Bacopa Aerial Parts Std. Extract (Bacopa monnieri (10-20:1); 12% Bacosides; 1.5 to 3 g Dried Equivalent)

50 mg Ginger (Zingiber officinale) Rhizome Std. Extract (14.6:1) (5% Gingerols; 730 mg Dried Equivalent).

Non-medicinal ingredients: Hypromellose, cellulose, silica, sunflower lecithin, stearic acid, maltodextrin, ascorbyl palmitate.

Longvida and BACOGNIZE are both trademarked products of Verdure Sciences, Inc.

This is a Non-GMO, Vegetarian, and Vegan product which is also Dairy Free, Gluten-Free, and Soy Free, and does not contain FOS.

Suggested Usage:

Adults: Take 2 capsules daily or as recommended by your healthcare practitioner. Use for a minimum of 6 weeks to see beneficial effects. Consult your healthcare practitioner if symptoms persist or worsen thereafter.


Keep out of reach of children. Consult your healthcare practitioner prior to use if you are pregnant or breastfeeding, or taking antiplatelet medication or blood thinners, or have gallstones, a bile duct obstruction, stomach ulcers or excess stomach acid. May cause digestive problems.

Health Canada Natural Product Number: 80067711.

Supporting Science:

Regarding Bacopa and Bacognize:

Abdul Manap AS, et al. “Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies.” Drug Target Insights, 2019.

Brimson, James M et al. “The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data.” Scientific Reports, 2021.

Goswami, Shishir et al. “Effect of Bacopa monnieri on Cognitive functions in Alzheimer’s disease patients.” International Journal of Collaborative Research on Internal Medicine & Public Health, 2011.

Hingorani, L et al. “Sustained cognitive effects and safety of HPLC-standardized Bacopa Monnieri extract: A randomized, placebo controlled clinical trial.” Planta Medica, 2012.

Kumar, Navneet et al. “Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial.” Evidence-Based Complementary and Alternative Medicine, 2016.

Regarding Ginger:

Ho, Su-Chen et al. “Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol.” Food Chemistry, 2013.

Li, Dan-Qi et al. “Network pharmacology-based approach to investigate the mechanisms of Zingiber officinale Roscoe in the treatment of neurodegenerative diseases.” Journal of Food Biochemistry, 2022.

Mao, Qian-Qian et al. “Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe).” Foods, 2019.

Saenghong, Naritsara et al. “Zingiber officinale Improves Cognitive Function of the Middle-Aged Healthy Women.” Evidence-based Complementary and Alternative Medicine (eCAM), 2012.

Talebi, Marjan et al. “Zingiber officinale ameliorates Alzheimer's disease and Cognitive Impairments: Lessons from preclinical studies.” Biomedicine & Pharmacotherapy, 2021.

Regarding LONGVIDA and Curcumin:

Cox, Katherine H M et al. “Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population.” Journal of Psychopharmacology (Oxford, England), 2015.

Cox, Katherine H M et al. “Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study.” Nutrients, 2020.

Jamwal, Rohitash. “Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers.” Journal of Integrative medicine, 2018.

Jin, Tian et al. “Curcumin can improve Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways.” Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 2022.

Koo, Bang-Bon et al. “Long-term effects of curcumin in the non-human primate brain.” Brain Research Bulletin, 2018.

Sarraf, Payam et al. “Short-term curcumin supplementation enhances serum brain-derived neurotrophic factor in adult men and women: a systematic review and dose-response meta-analysis of randomized controlled trials.” Nutrition Research, 2019.

UPC / Barcode: 883196150809