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Metagenics SpectraZyme Gluten Digest

Metagenics - SpectraZyme Gluten Digest

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Info: 90 Capsules

If you're trying to follow a gluten-free diet, you know that can be a real challenge, particularly if you're on the go, and sometimes no suitable options are available when you eat out or go to someone's house for dinner. This new product features an enzyme specifically targeted at breaking down the component of gluten which causes gluten-intolerant people so much grief, and it's designed to work within the stomach, to help break it down before it reaches the small intestine to do its damage.

Product Notes:

SpectraZyme Gluten Digest should not be regarded as a viable substitute for a gluten-free diet, however, nor as a means of treating or preventing celiac disease, and results may vary, depending on how much additional protein was eaten with the meal. But its key ingredient has definitely been shown to be able to break down gluten, making it a good backup support for those avoiding dietary gluten who want something to help digest (rather than waste) a meal, those times you're too reluctant or unable to insist on a completely gluten-free meal.

People with gluten intolerance who have difficulty digesting foods or beverages containing wheat, barley or rye -- possibly along with items which have been cross-contaminated with those cereal grains somewhere along their production chain -- are unable to fully break down a component of wheat gluten or the homologous storage proteins of barley and rye called prolamin peptides (an amino acid).

That undigested prolamin wreaks havoc on the microvilli or hair-like structures of the small intestine -- causing them to get flattened down, unable to do their job of absorbing nutrients from the foods which pass through. This can lead to inflammation and bloating, gas, feeling cold, and various other symptoms after eating (even bleeding) -- and can result in virtually your whole meal being literally wasted.

The Tolerase® G in this product is a unique type of endoprotease (also called proteolytic peptidases -- an enzyme that can break proteins' long, chainlike molecules down into shorter fragments called peptides, and then to their smaller components, amino acids) that specifically targets proline. It has been isolated from Aspergillus niger -- a type of fungus (like the black mold which grows on fallen leaves) that can be fermented to produce very useful enzymes which can be isolated to help make food items or digestive aids such as corn syrup, cider, and the digestive enzyme called "Beano," for example. This particular proline-specific endoprotease isolated in Tolerase® G has been shown to help break down gluten proteins in humans, both in vitro and in a gastrointestinal model.


Each capsule contains:
Prolyl Endopeptidase* (from Aspergillus niger): 200 mg, or 116,000 PPI, or 437 FCC HUT

Non-medicinal ingredients: Cellulose, capsule (hydroxypropyl-methylcellulose), stearic acid, magnesium stearate (vegetable source), and silicon dioxide.

*as Tolerase® G, which is a registered trademark of DSM.

Suggested Usage:

Adults: Take 1 or 2 capsules with each meal, or as directed by your healthcare practitioner. Store in a cool, dry place.


Consult healthcare practitioner prior to use if you are pregnant or breastfeeding; or if you are taking medication or other nutritional supplements. Not intended to replace a gluten-free diet. Not intended to treat or prevent celiac disease. If symptoms persist or worsen, consult a healthcare practitioner. Consult a healthcare practitioner prior to use if you have a gastrointestinal lesion/ulcer; or if you are taking an anticoagulant/blood thinner or an anti-inflammatory; or if you are having surgery. Hypersensitivity/allergy has been known to occur; in which case, discontinue use. Health Canada Natural Product Number: 80068377.

Canadian product label differs slightly from the one shown.

Supporting Science:

Alvarez-Sieiro P, Martin MC, Redruello B, Del Rio B, Ladero V, Palanski BA, Khosla C, Fernandez M, Alvarez MA. "Generation of food-grade recombinant Lactobacillus casei delivering Myxococcus xanthus prolyl endopeptidase." Appl Microbiol Biotechnol. 2014 Aug;98(15):6689-700.
doi: 10.1007/s00253-014-5730-7

Gass J, Bethune MT, Siegel M, Spencer A, Khosla C. "Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue." Gastroenterology. 2007 Aug;133(2):472-80.

Eugster PJ, Salamin K, Grouzmann E, Monod M. "Production and characterization of two major Aspergillus oryzae secreted prolyl endopeptidases able to efficiently digest proline-rich peptides of gliadin." Microbiology. 2015 Dec;161(12):2277-88. doi: 10.1099/mic.0.000198.

Janssen G, Christis C, Kooy-Winkelaar Y, Edens L, Smith D, van Veelen P, Koning F. "Ineffective degradation of immunogenic gluten epitopes by currently available digestive enzyme supplements." PLoS One. 2015 Jun 1;10(6):e0128065. doi: 10.1371/journal.pone.0128065.

Kaukinen K, Lindfors K. "Novel treatments for celiac disease: glutenases and beyond." Dig Dis. 2015;33(2):277-81. doi: 10.1159/000369536. .

Mitea C, Havenaar R, Drijfhout JW, Edens L, Dekking L, Koning F. "Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease." Gut. 2008 Jan;57(1):25-32. Epub 2007 May 9.

Montserrat V, Bruins MJ, Edens L, Koning F. "Influence of dietary components on Aspergillus niger prolyl endoprotease mediated gluten degradation." Food Chem. 2015 May 1;174:440-5. doi: 10.1016/j.foodchem.2014.11.053.

Salden BN, Monserrat V, Troost FJ, Bruins MJ, Edens L, Bartholomé R, Haenen GR, Winkens B, Koning F, Masclee AA. "Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers." Aliment Pharmacol Ther. 2015 Aug;42(3):273-85. doi: 10.1111/apt.13266.

Toft-Hansen H, Rasmussen KS, Staal A, Roggen EL, Sollid LM, Lillevang ST, Barington T, Husby S. "Treatment of both native and deamidated gluten peptides with an endo-peptidase from Aspergillus niger prevents stimulation of gut-derived gluten-reactive T cells from either children or adults with celiac disease." Clin Immunol. 2014 Aug;153(2):323-31. doi: 10.1016/j.clim.2014.05.009.

UPC Code: 755571945570