Info: 60 or 120 Softgels
Don't block it. Resolve it! SPM Active is a revolutionary new approach to dealing with chronic inflammation, based on the new scientific understanding of the inflammation process and extensive preclinical research. Rather than just masking or blocking pain, the omega-3 concentrate in SPM Active works to actively resolve chronic inflammation and facilitate healing.
Info: 60 or 120 Softgels
Don't block it. Resolve it! SPM Active is a revolutionary new approach to dealing with chronic inflammation, based on the new scientific understanding of the inflammation process and extensive preclinical research. Rather than just masking or blocking pain, the omega-3 concentrate in SPM Active works to actively resolve chronic inflammation and facilitate healing.
Product Notes:
What is SPM Active?
While conventional pain killers may help to block pain after the initial stages of an injury are over, SPM Active works to actually reduce or even eliminate ongoing inflammation that's causing the pain. A marine lipid concentrate, SPM Active provides a concentrated dose of the same substance the body uses to actively resolve inflammation – facilitating healing and helping to maintain a healthy state.
How Do Specialized Pro Resolving Mediators Work?
It's been long understood that there are three main stages to inflammation - acute (the swelling stage), sub-acute (repair and regeneration), and chronic (remodelling and maturation) - hopefully followed by a return to a pain-free homeostasis. But until quite recently, scientists didn't fully understand all the biological mechanisms involved in passing from one phase to the next.
In particular, it used to be thought that final resolution phase - the transition from the chronic inflammation stage to homeostasis - was a passive affair: that it would just play itself out when all the scar tissue and healing is done. However, thanks largely to the work of the Stanford and Harvard researcher Charles Serhan, it's now known that this is an active process, accomplished by specialized pro-resolving mediators (SPMs).
These SPMs, which are naturally present in our bodies and can also be found as components of the EPA and DHA essential fatty acids found in certain oils, increase phagocytic activity. That is, they initiate macrophages to act like 'Pacmen' to remove the apoptotic neutrophils (a type of white blood cell) and accumulated fibrous debris at the scene which are sustaining the inflammation and associated pain.
Metagenics has built on that work by doing extensive preclinical research and developing patent-pending technology to isolate, measure, and verify the most relevant types of SPMs responsible for that activity, and finding a way to extract standardized levels of them from fish oil, using advanced fractionation technology. The results are so concentrated that you would need to consume five gallons of fish oil to get an equivalent amount of these key compounds!
Mediators of Inflammation and More
Now available in Canada, this product has been in use in the United States since early 2017, and doctors are finding it helps with a wide range of inflammatory conditions, including not only rheumatoid or osteoarthritis, but also gastrointestinal problems like Irritable Bowel Syndrome or Crohn's, as well as fibromyalgia. Studies also indicate it should be of use in preventing metabolic co-morbidities associated with obesity, or even relieving the pain from tooth decay (dental pulp inflammation: pulpitis).
SPM Active from Metagenics was originally launched as part of their OmegaGenics line in some markets. While they have different labels, the Canadian and American SPM Active products are exactly the same. Labelling regulations are different in each country, and in the USA the active ingredient is listed as 1 gram of Active Fractionated Marine Lipid Concentrate per serving (2 softgels), with its SPM content standardized to 18-hydroxy-eicosapentaenoic acid (18-HEPE), 17-hydroxy-docosahexaenoic acid (17-HDHA) and 14-hydroxy-docosahexaenoic acid (14-HDHA).
Video Transcript (from above)
SPM Active - Don't block it. Resolve it!
When the body experiences physical stress from overexertion, unhealthy diet, or the normal aging process, the immune response triggers the production of specialized pro-resolving mediators - referred to as SPMs. SPMs support the body's natural capacity to respond to physical challenges and resolve physical stress.
Think of your body as a forest. Most of the time it's a peaceful place where everything is in balance, but when the body experiences an unexpected event or physical stress, it sparks an immune response. This is also called the initiation phase. If the conditions are vulnerable, that spark can grow into a fire. While the body is naturally equipped to deal with a fire, it may need backup to help keep things under control. Once the immune response has been fully extinguished - or resolved - the body continues its natural and healthy balance, and like a forest, the body can flourish.
SPM Active is that firefighter, that helps facilitate the resolution of the immune response. SPM Active is a marine lipid concentrate with specialized pro-resolving mediators that offers a nutritional approach to assisting the body from moving from the initiation phase of dealing with physical stress to the resolution phase. SPM Active is researched and designed to support the needed SPMs in your body.
SPM Active Ingredients:
Each softgel of SPM Active contains:
500 mg of Fish Oil (derived from a blend of sardine, anchovy and mackerel), providing 50 mg EPA and 100 mg DHA.
Non-medicinal ingredients: Mixed tocopherol concentrate, softgel shell (gelatin, glycerin, and water), and silica.
This product is non-GMO and gluten-free.
Suggested Usage:
Adults: Take 2 capsules daily, or as recommended by a healthcare practitioner.
Please note, for the original formulation, based on the clinical experience in developing the product, Metagenics recommended beginning with a loading dose of 6 softgels per day for the first 4 weeks for those who are starting with serious pain related to arthritis and chronic inflammation, then a transition phase of 4 softgels a day for the next 4 weeks, before going to that maintenance dose of 2 softgels a day.
But with this new and improved version, no loading dose is needed! The soft gels are now twice the size of the original version (but are still small enough to swallow) with double the amount of fish oil per capsule, yielding three times as much of the two key factors (17-HDHA and 18-HEPE) per dose, compared to the original SPM Active.
Warnings:
Keep bottle tightly closed in a cool, dry place. Side effects? SPM Active has no known risks or counter-indications.
Health Canada Natural Product Number: 80091339.
Supporting Science:
Aubeux, Davy et al. “Specialized pro-resolving lipid mediators in endodontics: a narrative review.” BMC Oral Health, 2021.
Cagnina, R Elaine et al. “Specialized pro-resolving mediators in respiratory diseases.” Current Opinion in Clinical Nutrition and Metabolic Care, 2022.
Clària, Joan et al. “Pro-resolving actions of SPM in adipose tissue biology.” Molecular Aspects of Medicine, 2017.
Kraft, Jamie D et al. “Specialized Pro-Resolving Mediators and the Lymphatic System.” International Journal of Molecular Sciences, 2021.
Ji, Ru-Rong. “Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch.” Annual Review of Pharmacology and Toxicology, 2023.
Souza, Patricia R et al. “Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses: A Randomized Double-Blind Placebo-Controlled Study.” Circulation Research, 2020.
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