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Petadolex (Butterbur Extract)

Petadolex (Butterbur Extract)

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Info: 60 Capsules (75 mg Each)

Now available in Canada again! Research supports the ability of butterbur extract to support healthy blood vessel tone in the neck and brain, which acts as an anti-inflammatory and can help reduce the frequency of migraine headaches and help with tension headaches.

Info: 60 Capsules (75 mg Each)

Now available in Canada again! Research supports the ability of butterbur extract to support healthy blood vessel tone in the neck and brain, which acts as an anti-inflammatory and can help reduce the frequency of migraine headaches and help with tension headaches.

Product Notes:

Does your migraine prescription put you at risk for liver damage, hair loss, fatigue, memory problems or even rebound headaches?

Prescribed by European neurologists since 1972, Petadolex butterbur extract has been safely used by millions of migraine sufferers to reduce migraine frequency and severity.

The Butterbur extract recommended by The Canadian Headache Society

Petadolex is a standardized extract of Petasites hybridus made with an exclusive methodology to extract the key bioactive compounds Petasin and Isopetasin from the root of the plant, while eliminating the toxic pyrrolizidine alkaloids (PAs) that are naturally present in all parts of butterbur.

In a clinical study, 71% of participants reported that the 75mg strength Petadolex cut their migraine attacks IN HALF. Less pain medication is needed less often!

While there are other brands of Butterbur, only Petadolex gel capsules are guaranteed to be:
* Safe and Well-Tolerated: with no harmful side effects and no known drug interactions
* Proven: clinically tested for migraines in US migraine centers - unlike beta blockers, anticonvulsants and Botox
* Pure: at least 15% Petasin herbal extract with zero detectable pyrrolizidine alkaloids - PA-free
* Affordable: No prescription needed.

Preventive treatment to reduce the frequency of migraine headaches and associated symptoms as well as for the symptomatic relief of seasonal rhinitis. Are you suffering from migraines? If you suffer from debilitating headaches, here's some good news.

Petadolex contains a standardized extract from the butterbur plant. Butterbur (Petasites hybridus) was mentioned by the ancient Greeks around 100 AD. It was used in the middle ages to treat the plague. In traditional phytotherapy, Petasites hybridus is described as having spasmolytic (muscle-relaxing) effects.

Natural Relief for Migraine Sufferers

Migraines are linked to levels of the brain hormone serotonin. Best known as the hormone that regulates mood, serotonin also has an effect on blood vessels. High serotonin levels keep blood vessels constricted, while low serotonin levels cause them to dilate, or swell. It is the swelling of blood vessels in the brain that causes migraines.

There are two types of migraines: classic migraines are often preceded by changes in vision called aura. It is possible to experience a classic migraine without headache. Auras do not precede common migraines, which involve pulsing, throbbing, or aching pain, often on just one side of the head.

Migraines may also be accompanied by nausea and vomiting. A variety of things may trigger migraines, including some foods and drugs, bright lights or loud noises, changes in weather or altitude, stress or fatigue, low blood sugar, or hormonal fluctuations accompanying menstruation.

How Petadolex Helps Migraines

Petadolex is made from an herb called Butterbur (Petasites hybridus). The active ingredients in this herb inhibit the synthesis in the body of certain leukotrienes, substances that can cause spasms and inflammation. It is the antispasmodic effect that seems to provide effective support against migraines.

In one study of 60 migraine sufferers, patients received either Petadolex or placebo twice daily for 12 weeks. Starting around the fourth week and continuing to the end of the study, the Petadolex group experienced up to a 60 percent reduction in number of migraines compared with the placebo group. The Petadolex group also reduced intensity of migraines, and a reduction in accompanying migraine symptoms such as nausea and vomiting.

In another study, this one involving over 200 migraine sufferers, participants experienced up to 51 percent reduction in frequency, severity, and duration of migraines compared with individuals who took placebo.

Other Important Points about Petadolex

Petadolex is a medicinal preparation of purple butterbur (Petasites hybridus), also known as sweet coltsfoot. Although this herb has been used in traditional herbal medicine for centuries, only a medicinal preparation [standardized to 15 percent petasin and isopetasin and with pyrrolizidine alkaloids (PAs) reduced to less than .01 parts per million (ppm)] is recommended for therapeutic purposes. Petadolex meets these requirements and is considered safe for adults and children over 12.

Petadolex may also be useful for other spasmodic conditions, such as digestive tract spasms, lower back pain, and asthma.

Branding Note on Butterbur: Petadolex® is a medicinal preparation of purple butterbur (Petasites hybridus), with a registered trademark by Weber & Weber GmbH & Co KG (A Pascoe product in Canada).

Related Product: Also see NOW Butterbur with Feverfew.

Petadolex Ingredients:

Each capsule contains:

75 mg Petadolex butterbur (Petasites hybridus) rhizome extract (36:1) of (equivalent to 2.7 g of butterbur root, providing 11.25 mg of petasin and isopetasin).

Non-medicinal ingredients: Medium-chain triglycerides, gelatin, glycerol, sorbitol, olive oil, purified water, and natural mixed carotenoids.

Suggested Usage:

Adults: Take one capsule two times daily. Consult a healthcare practitioner for use beyond 4 months.

Store bottle in a cool, dry place. Any colour changes in the softgels are a result of natural oxidization and do not affect their efficacy.


Keep out of reach of children. Do not use if you are pregnant or breastfeeding, or if you are allergic to plants of the Asteraceae/Compositae/Daisy family, or if you have any liver disease. Not suitable for people with hepatitis and/or chronic alcohol abuse. Stop use and consult a health care practitioner if you develop symptoms of liver trouble such as yellowing of the skin/eyes (jaundice), stomach pain, dark urine, sweating, nausea, unusual tiredness and/or loss of appetite. Hypersensitivity/allergy is known to occur; in which case, discontinue use.

Health Canada Natural Product Number: 80107351.

Supporting Science:

Borlak, Jürgen et al. “Petasites for Migraine Prevention: New Data on Mode of Action, Pharmacology and Safety. A Narrative Review.” Frontiers in Neurology, 2022.

Danesch, Ulrich C. “Petasites hybridus (Butterbur root) extract in the treatment of asthma--an open trial.” Alternative Medicine Review: A Journal of Clinical Therapeutic, 2004.

Grossman, W, and H Schmidramsl. “An extract of Petasites hybridus is effective in the prophylaxis of migraine.” Alternative Medicine Review: A Journal of Clinical Therapeutic, 2001.

Pothmann, Raymund, and Ulrich Danesch. “Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract.” Headache, 2005.

Canadian Headache Society Guideline for Migraine Prophylaxis. Volume 39 (Number 2, Supplement 2). March 2012.

UPC / Barcode: 4039343179094