Info: 60 Vegetarian Capsules
Although estrogen is needed to maintain sexual health in both women and men, excessive levels of it can lead to a cluster of symptoms or even certain forms of cancer in both sexes. Instead of compounding the problem by trying to produce excessive levels of its balancing hormones progesterone or testosterone, this formula supplies Diindolylmethane (DIM) to get our bodies to produce less of the potentially harmful forms of estrogen along with a blend of antioxidants and methyl donors to help our liver's phase II detoxification pathway deal with the excess.
Info: 60 Vegetarian Capsules
Although estrogen is needed to maintain sexual health in both women and men, excessive levels of it can lead to a cluster of symptoms or even certain forms of cancer in both sexes. Instead of compounding the problem by trying to produce excessive levels of its balancing hormones progesterone or testosterone, this formula supplies Diindolylmethane (DIM) to get our bodies to produce less of the potentially harmful forms of estrogen along with a blend of antioxidants and methyl donors to help our liver's phase II detoxification pathway deal with the excess.
Product Notes:
Higher than normal estrogen levels can affect both women (where its called estrogen dominance) and men, leading initially to symptoms like low libido, sleep disturbance, breast pain, water retention, brain fog, acne, and mood disorders in women, or 'man boobs', low fertility, ED, or a similar cluster of fatigue, lack of energy, and mood changes in men.
Sometimes, this may due to the accumulation of "xenoestrogens" and/or endocrine disrupting chemicals, which are man-made chemicals like the Bisphenol A (BPA) in plastic bottles that can trick our estrogen receptors into thinking they're the real deal, and which may get taken up and stored for later use in our fat tissues, and released if we burn that fat while dieting or exercising.
Normally, our livers break down the unneeded circulating estrogen and send it to the bowels to be eliminated, but if there's too much of it, or if a person is often constipated and it stays there too long, there can be problems.
This formula is designed to improve this issue with a three-pronged approach, by including: a particularly well-absorbed form of DIM, to help lower your body's own production of the stronger forms of estrogen; a blend of antioxidants to work with the DIM in assisting the liver in its detoxification process; and, to beat the xenoestrogens at their own game, a special type of lignan that our bodies can convert to a much friendlier (it's believed to be more likely to protect against breast or prostate cancer than to cause it), plant-based estrogen analogue called enterolactone, to occupy some of the estrogen receptors, instead.
This product is known simply as "DIM Detox" in the USA.
DIM Enhanced Ingredients:
Each capsule contains:
100 mg DL-Alpha-lipoic-acid
100 mg N-Acetyl-L-cysteine
100 mg L-Methionine
75 mg Milk thistle (Silybum marianum) Seed Std. Extract (standardized to contain 80% silymarin)
50 mg BioResponse DIM® - a complex of Starch, 3,3’-diindolylmethane (aka DIM, with 12.5 mg of that per capsule), Vitamin E, Phosphatidylcholine, and Silica)
50 mg Broccoli (Brassica oleracea var. italica) Sprout Std. Extract (20:1, 1000 mg dried equivalent) (standardized to contain 200 mcg sulforaphane)
50 mg Calcium D-Glucarate
50 mg Glycine
50 mg Taurine
5 mg HMRlignan™ 7-hydroxymatairesinol potassium acetate
Non-medicinal ingredients: Hydroxypropyl methylcellulose, Hypoallergenic plant cellulose, Ascorbyl palmitate, Purified water.
BioResponse DIM® is a trademark of BioResponse, L.L.C., Boulder, CO.
HMRlignan™ is patented by Linnea, a partner of Biogredia (a Swiss manufacturer); it is a powerful antioxidant extracted from the wood knots of Picea abies L. (Norway Spruce), which can help reduce neuroinflammation, brain aging, and menopausal hot flashes.
Suggested Usage:
Adults: Take 2 capsules daily with meals, or as directed by a healthcare practitioner. Ensure that you drink enough fluid before, during, and after exercise. Consult a healthcare practitioner for use beyond 8 weeks. Store in a cool, dry place.
Warnings:
Keep out of the reach of children. Do not use DIM & Detox if you are pregnant or breastfeeding or taking antibiotics or nitroglycerin. Consult a healthcare practitioner prior to use if you are attempting to conceive; or if you have diabetes, kidney stones, liver disorder, or symptoms of low estrogen; or if you are taking contraceptives, hormone replacement therapy, or indeed any medication or natural health products. Stop use and consult a healthcare practitioner if symptoms persist or worsen, if you develop liver-related symptoms, symptoms of low estrogen, or if you experience sweating, paleness, chill, headache, dizziness or confusion. Stop use if allergy occurs.
Health Canada Natural Product Number: 80073707.
Supporting Science:
“3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans.” Drug Metabolism and Disposition: The Biological Fate of Chemicals, 2021.
“3,3'-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis.” Cells, 2021.
“Anticancer and antimetastatic potential of enterolactone: Clinical, preclinical and mechanistic perspectives.” European Journal of Pharmacology, 2019.
“Antioxidant function of isoflavone and 3,3'-diindolylmethane: are they important for cancer prevention and therapy?” Antioxidants & Redox Signaling, 2013.
“Bisphenols Threaten Male Reproductive Health via Testicular Cells.” Frontiers in Endocrinology, 2020.
“Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention.” Reviews in Endocrine & Metabolic Disorders, 2020.
“Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection.” Current Drug Metabolism, 2016.
“Physiological modeling of formulated and crystalline 3,3'-diindolylmethane pharmacokinetics following oral administration in mice.” Drug Metabolism and Disposition: The Biological Fate of Chemicals, 2004.
“Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin.” Food and Chemical Toxicology, 2007.
“Risks and benefits related to alimentary exposure to xenoestrogens.” Critical Reviews in Food Science and Nutrition, 2017.
“Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis.” Nutrients, 2021.
“The impact of metalloestrogens on the physiology of male reproductive health as a current problem of the XXI century.” Journal of Physiology and Pharmacology, 2019.
“The male mammary gland: a target for the xenoestrogen bisphenol A.” Reproductive Toxicology (Elmsford, N.Y.), 2013.
“Xenoestrogens impact brain estrogen receptor signaling during the female lifespan: A precursor to neurological disease?” Neurobiology of Disease, 2022.
“Zearalenone and its metabolites: Effect on human health, metabolism and neutralisation methods.” Toxicon: Official Journal of the International Society on Toxinology, 2019.