Info: 60 Vegetarian Capsules
Just as general health guidelines on risk factors and preventive measures may be based on research lacking much diversity in its subjects, nutritional recommendations can overlook how genetic variations can impair the effects of regular vitamins or minerals. To compensate for those variations (which you may know you have already, or which can be identified for you through their PureGenomics program), Pure Encapsulations has created this formulation featuring either alternate forms or doses of the affected nutrients.
Info: 60 Vegetarian Capsules
Just as general health guidelines on risk factors and preventive measures may be based on research lacking much diversity in its subjects, nutritional recommendations can overlook how genetic variations can impair the effects of regular vitamins or minerals. To compensate for those variations (which you may know you have already, or which can be identified for you through their PureGenomics program), Pure Encapsulations has created this formulation featuring either alternate forms or doses of the affected nutrients.
Product Notes:
"Nutrigenomics" is a relatively new scientific discipline that uses cutting-edge genomics technology to study the link between people's nutrition, genes, and health. PureGenomics™ is a nutrigenomics service Pure Encapsulations has developed to enable people to make informed lifestyle and supplement choices tailored to their unique wellness needs and goals. It's free, but can only be set up through your healthcare provider, using the genetic data profiles obtained from a completed Ancestry® or a 23andMe® test kit.
Those genetic profiles can identify a number of common genetic variations and their associated trait categories, which PureGenomics then runs through its database to identify which ones are not only relevant to a person's health status but also validated by published research and responsive to nutritional support.
Some of these variations (which are called Single Nucleotide Polymorphisms, or SNPs or 'snips' for short) can affect how the body breaks down and uses nutrients, making one more vulnerable to developing deficiencies and possible health problems unless one either takes a higher amount or a more bioavailable form than normal.
Accordingly, this multivitamin formulation uses activated forms of B vitamins and includes choline to address the altered nutritional requirements of those with fairly common genetic variations that can reduce the efficiency of the "methylation" processes using them, and highly bioavailable forms of vitamins A, C, D, E and K for those with traits imposing additional requirements for them, all in a convenient one capsule per-day dose.
PureGenomics Multivitamin Ingredients:
Each vegetarian capsule contains:
Vitamin A (vitamin A acetate): 822 mcg RAE (2750 IU)
Beta-carotene (from Blakeslea trispora): 600 mcg
Vitamin C (ascorbic acid/ascorbyl palmitate): 180 mg
Vitamin D3 (cholecalciferol): 25 mcg (1000 IU)
Vitamin E (d-alpha tocopherol acid succinate): 20 mg AT (30 IU)
Vitamin K1: 60 mcg
Vitamin K2 (menaquinone-7): 20 mcg
Thiamine (thiamine hydrochloride, BenfoPure® benfotiamine): 6 mg
Riboflavin (riboflavin, riboflavin 5'-phosphate): 3 mg
Niacin (niacinamide): 20 mg
Vitamin B6 (pyridoxine hydrochloride, pyridoxal 5'-phosphate): 4 mg
Folate (calcium L-5-methyltetrahydrofolate, Metafolin®): 800 mcg
Vitamin B12 (hydroxocobalamin/adenosylcobalamin): 1000 mcg
Biotin: 300 mcg
Pantothenic acid (calcium d-pantothenate): 10 mg
Iodine (potassium iodide): 150 mcg
Zinc (zinc citrate): 25 mg
Selenium (selenomethionine): 70 mcg
Manganese (manganese citrate): 2 mg
Chromium (chromium polynicotinate): 200 mcg
Molybdenum (TRAACS®) (molybdenum bisglycinate): 75 mcg
Boron (boron glycinate): 1 mg
Choline (choline bitartrate): 57 mg
Inositol: 25 mg
Lutein (®FloraGLO) (from Tagetes erecta herb flowering oleoresin): 3 mg
Zeaxanthin (from Tagetes erecta herb flowering oleoresin): 500 mcg
Non-medicinal ingredients: Vegetarian capsule (hypromellose, water), magnesium citrate.
This product is Certified Gluten-Free by the Gluten-Free Certification Organization, and it is also GMO free and suitable for vegetarians.
BenfoPure® is a registered trademark of Hamari Chemicals USA, Inc.
ChromeMate® brand niacin-bound chromium and its logo are trademarks of Lonza or its affiliates.
FloraGLO® is a registered trademark of Kemin Industries, Inc.
Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany.
TRAACS® is a registered trademark of Albion Laboratories, Inc.
Zeaxanthin is sourced from OPTISHARP™ brand. OPTISHARP™ is a trademark of DSM Nutritional Products, Inc.
Suggested Usage:
Adults: Adults: Take 1 capsule daily with a meal containing oil and calcium, a few hours before or after taking other medications or natural health products, or as recommended by a healthcare practitioner.
Store bottle tightly sealed in a cool, dry place.
Please be advised that users report this formulation smells far more "herbal" than most vitamins, but this is normal.
Warnings:
Keep out of reach of children. Do not use if you are allergic to plants of the Asteraceae/Compositae/Daisy family. Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, or if you are taking blood thinners, or if you have a kidney disorder, or have been diagnosed with estrogen-dependent cancer, or have a history of non-melanoma skin cancer.
Health Canada Natural Product Number: 80078284.
Supporting Science:
“Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review.” Nutrients, 2021.
“Dietary Choline Intake during Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-Control Study.” Annals of Nutrition & Metabolism, 2020.
“Dietary intake of vitamin A, lung function and incident asthma in childhood.” The European Respiratory Journal, 2021.
“Genotype Effects on β-Carotene Conversion to Vitamin A: Implications on Reducing Vitamin A Deficiency in the Philippines.” Food and Nutrition Bulletin, 2022.
“Hereditary Metabolic Bone Diseases: A Review of Pathogenesis, Diagnosis and Management.” Genes, 2022.
“High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms.” The American Journal of Clinical Nutrition, 2002.
“Impact of KCNJ11 rs5219, UCP2 rs659366, and MTHFR rs1801133 Polymorphisms on Type 2 Diabetes: A Cross-Sectional Study.” The Review of Diabetic Studies: RDS, 2021.
“Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project.” BMC Medicine, 2020.
“Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism.” Human Mutation, 2007.
“Methylenetetrahydrofolate Reductase Deficiency.” Medical Genetics Summaries, edited by Victoria M. Pratt et al., National Center for Biotechnology Information (US), 8 March 2012.
“Polymorphisms Contributing to Calcium Status: A Systematic Review.” Nutrients, 2021.
“Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty.” The Journal of Nutrition, Health & Aging, 2010.
Partial List of Genetic Variations Affecting the Metabolism of Certain Vitamins and Thrust of Some Supporting Studies for Why Alternative, More Bioavailable, or Higher Dose Forms May Be Needed
Vitamin B6: CBS (rs234706) - The T allele is associated with lower vitamin B6 (pyridoxine) levels, which may increase the risk of non-Hodgkin lymphoma (NHL).
Vitamin B6: NBPF3 (rs4654748) - The C allele is associated with lower vitamin B6 (pyridoxine) levels, which may result in higher homocysteine levels and increase the risk of heart disease.
Folate: MTHFR C677T (rs1801133) - The T allele is associated with a reduced capacity to convert folic acid and other precursors to its activated form, folate, which may result in elevated blood homocysteine concentration and increase the risk of stroke.
Folate: MTHFR A1298C (rs1801131) - The C allele is associated with a reduced capacity to convert folic acid and other precursors to its activated form, folate, which can elevate homocysteine levels, and prevent B-vitamins from having a therapeutic effect on major depression.
Choline: MTHFD1 (rs2236225) - The A allele is associated with a reduced capacity for choline production, increasing the need for dietary or supplementary sources.
Choline: PEMT (rs7946) - The A allele is associated with a reduced capacity for choline production, which may increase women's risk of breast cancer if their choline intake is not increased.
Vitamin B12: TCN2 (rs1801198) - The G allele is associated with a lower capacity to absorb and/or transport vitamin B12 (cobalamin) to parts of the body that need it, in European-descent subjects; Vitamin B-12 (cobalamin) deficiencies can be associated severe neurologic and hematologic manifestations.
Vitamin B12: FUT2 (rs602662) - The GG variant is associated with a lower capacity to absorb and/or transport vitamin B12 (cobalamin) to parts of the body that need it - but mostly in Caucasian populations.
Vitamin B12: MTRR (rs1801394) - The G allele is associated with a lower capacity to absorb and/or transport vitamin B12 (cobalamin) to parts of the body that need it, which decreases the ability of B-vitamins to decrease the pain and severity of migraine with aura in female migraineurs.
Vitamin B12: MTR (rs1805087) - The G allele is associated with a lower capacity to absorb and/or transport vitamin B12 (cobalamin) to parts of the body that need it, which elevates the risk of Hyperhomocysteinemia (HHcy), an independent risk factor for cardiovascular diseases in Chinese people with hypertension.
Vitamin D: GC (rs2282679) - The G allele is associated with an increased vitamin D requirement, to avoid an increased risk of prostate cancer in men with low vitamin D status, or to lower the risk of diabetes in European and Chinese adults.
Vitamin D: DHCR7 (rs12785878) & CYP2R1 (rs10741657) - The G allele is associated with an increased vitamin D requirement, mostly in the Caucasian or European descent population.
Vitamin E: Intergenic (rs12272004) - Those with the A allele may have slightly lower levels of circulating vitamin E (alpha-tocopherol), which may increase the risk of chronic disease and disability.
Zinc: SLC30A8 (rs11558471) - Those with the A allele are more likely to have increased zinc requirements, to reduce the risk of raising fasting glucose levels among people with European ancestry.