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Douglas Laboratories - Rest Reset

Douglas Laboratories - Rest Reset

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Info: 30 Veg. Capsules; Limited Quantity Available

Rest Reset is a unique advanced formula which combines three types of medicinal ingredients to promote a more restful sleep by addressing several areas which impact that. It features Lactium, the star of Douglas Labs' companion product, Serinten Plus.

Info: 30 Veg. Capsules; Limited Quantity Available

Rest Reset is a unique advanced formula which combines three types of medicinal ingredients to promote a more restful sleep by addressing several areas which impact that. It features Lactium, the star of Douglas Labs' companion product, Serinten Plus.

Product Notes:

Rest Reset was formulated by Dr. Penny Kendall-Reed, a nationally recognized naturopath specializing in metabolic and neuro-endocrine health, who has a more detailed presentation on the rationale for this product and the functions of its three medicinal ingredients in the "Supporting Science" section below.

The most abundant ingredient here for an immediate restful effect is passionflower, a traditional herbal medicine with a calming effect to counteract the restlessness or insomnia due to mental stress.

The other two replicate substances normally produced by people's (and animals') bodies to help them or their offspring get and stay sleep, and may take a little longer (like one or two weeks of regular use) to work in order to achieve a sleep Reset.

Melatonin helps ready our bodies for sleep and can increase total sleep time; we produce less of it as we age, and may also benefit from it if our normal sleep/wake cycles have been disrupted by shift work, traveling across time zones, or other circumstances. And the pièce de résistance is Lactium®, an extract of a specific kind of protein found in milk which functions to calm nursing infants (paired with an enzyme to enable adults to fully utilize it).

Lactium is a type of milk protein hydrolysate called "casein decapeptide" that's been extracted from milk using hydrolysis (a chemical reaction using water and enzymes). Its active ingredient is alpha-casozepine, a peptide (a complex molecule with a chain of amino acids like a protein, but with fewer members and less structure) with a selective affinity for a particular kind of brain receptor called GABA-α, which enables it to increase the activity of GABA (gamma-Aminobutyric acid), an important neurotransmitter with anti-anxiety, sedating, and muscle-relaxing effects which also fosters a sense of calmness and well-being. Of course, this alpha-casozepine can only accomplish those things if it's able to fully enter the bloodstream and cross the intestinal and blood-brain barriers, which is why the digestive enzyme trypsin has been included in the Lactium, since adults' digestive systems are less adept at breaking down these small milk protein chains than infants' are.

There have been at least seven rigorous clinical studies of Lactium, showing it is both safe and effective at the recommended doses, and notably absent of side-effects. Not only can it decrease the time it takes to fall asleep and improve the quality of one's sleep and how well one functions the next day, but it can also help prevent people's blood pressure and heart rate rising too much during stressful situations.


Each capsule contains:

425 mg Passionflower Aerial Parts Extract (Passiflora incarnata) (4-6:1; 1700-2550 mg dried equivalent)

175 mg Alpha S1-Casein Tryptic Hydrolysate (Lactium®)

3 mg Melatonin

Non-medicinal ingredients: Hypromellose (capsule), cellulose, silica, ascorbyl palmitate, hyprolose.

Contains: Milk. Please note, however, that Lactium® contains very little lactose (<0.5%) and therefore presents little risk of lactose intolerance at the recommended dosage.

Does not contain yeast, wheat gluten, corn, sodium, sugar, artificial colouring, preservatives or flavouring.

Lactium® is a registered trademark used under license.

Suggested Usage:

Adults: Take one capsule daily, 30 to 60 minutes before bedtime on an empty stomach, or as directed by your healthcare practitioner. Do not drive or use machinery for 5 hours after use. Consult a healthcare practitioner for use beyond 4 weeks.


Keep out of reach of children. Do not use Douglas Labs Rest Reset if you are pregnant or breastfeeding, or if you are allergic to milk protein.

Consult a healthcare practitioner prior to use if you have one of the following conditions - asthma, cardiovascular disease, chronic kidney disease, depression, diabetes or hypoglycaemia, hormonal disorder, immune system disease, liver disease, migraine, or seizure disorders - or if you are taking one of the following medications: anticoagulant, anticonvulsant, blood pressure medications, immunosuppressive medications, sedative, hypnotic or psychotropic medications, or steroids.

Consumption with alcohol, other medications or natural health products with sedative properties is not recommended. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness.

Mild gastrointestinal symptoms and rare allergic reactions have been known to occur in which case, discontinue use.

If symptoms worsen or sleeplessness persists continuously for more than 3 weeks (chronic insomnia), consult your healthcare practitioner.

Health Canada Natural Product Number: 80087186.

Supporting Science:

“Anxiolytic Activity and Brain Modulation Pattern of the α-Casozepine-Derived Pentapeptide YLGYL in Mice.” Nutrients, 2020.

“A Double-Blind, Randomized, Placebo-Controlled Crossover Clinical Study of the Effects of Alpha-s1 Casein Hydrolysate on Sleep Disturbance.” Nutrients, 2019.

“Effects of a bovine alpha S1-Casein tryptic hydrolysate (CTH) on sleep disorder in Japanese general population.” Open Sleep Journal, 2009.

“Effects of a tryptic hydrolysate from bovine milk alphaS1-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations.” European Journal of Nutrition, 2005.

“Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study.” International Clinical Psychopharmacology, 2020.

“Ethological comparison of the effects of a bovine alpha s1-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety.” Pharmacology, Biochemistry, and Behavior, 2006.

“Food protein-derived anxiolytic peptides: their potential role in anxiety management.” Food & Function, 2021.

[Improvement of Stress Resistance and Quality of Life of Adults with Nervous Restlessness after Treatment with a Passion Flower Dry Extract [article in German]]. Complementary Medicine Research, 2017.

“Long term effects of a bovine milk alpha-S1 casein hydrolysate on healthy low and high stress responders.” Stress, 2002.

[Melatonin as a regulator of human sleep and circadian systems]. Nihon rinsho. Japanese Journal of Clinical Medicine, 2012.

“New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation.” British Journal of Pharmacology, 2018.

UPC / Barcode: 310539978535