Info: 60 Veg. Capsules
New! Gout is a debilitating form of arthritis with several underlying factors which warrant a multi-faceted approach to manage effectively, including diet (to decrease up to a third of the waste product fueling it) and exercise. GOUTart contains a blend of 6 types of antioxidants and herbal medicines designed to not only help relieve the pain and inflammation associated with gout flare-ups in the short term but also to prevent them over the longer term.
Info: 60 Veg. Capsules
New! Gout is a debilitating form of arthritis with several underlying factors which warrant a multi-faceted approach to manage effectively, including diet (to decrease up to a third of the waste product fueling it) and exercise. GOUTart contains a blend of 6 types of antioxidants and herbal medicines designed to not only help relieve the pain and inflammation associated with gout flare-ups in the short term but also to prevent them over the longer term.
Product Notes:
Once characterized as the "Disease of Kings" for being associated with certain foods and drinks only the wealthy could afford in great quantities, gout now afflicts nearly 1 million Canadians (with nearly 80% of them being men over the age of 30).
Although the basic mechanics of gouty inflammatory arthritis are quite well understood (for details, see the first video and/or the final paragraph below*), it's still regarded as a multi-factorial process which can be aggravated by genetics, medications, age, and other health conditions as well as by alcohol and diet and lack of exercise, so some may need ongoing help even after addressing the lifestyle factors.
Consequently, this new Advanced Complex from Nutridom combines 6 powerful natural ingredients to tackle the multi-faceted problem in several different ways:
• Reducing the inflammation, swelling and pain with a combination of Curcumin (from Turmeric), Celery Seed, Devil's Claw, Tart Cherry, and Bromelain extracts.
• Reducing the excess levels of uric acid/MSU in three ways:
- by helping break down the crystal formations (with Tart Cherry and Bromelain);
- by helping us excrete more MSU before it gets to that stage (with Celery Seed, Devil's Claw and Tart Cherry extracts and Vitamin C – be sure to keep hydrated, to facilitate that); and,
- by inhibiting some of its production in the first place (with Celery Seed, which inhibits xanthine oxidase, the enzyme the liver uses to metabolize purines).
* [The fundamental mechanics of gout: Human livers produce uric acid (also called monosodium urate, or MSU) when metabolizing substances containing compounds called "purines." About a third of that production is due to certain foods and drink, but two-thirds is the unavoidable result of breaking down and recycling some of our own spent biomolecules such as Adenosine and ATP, and the RNA and DNA in our dead cells. That waste product then circulates in our bloodstreams, where it's meant to make its way to the kidneys to get broken down and excreted. But when there are excessive levels of it or the kidneys aren't performing optimally, that MSU can accumulate in the synovial fluid in the spaces of our joints (usually the big toe, to start with), and then crystallize, sort of like the spiky stalactite and stalagmite formations sometimes found in caves. If the joint then gets stubbed or bumped, that can release little shards of those MSU crystals, which then triggers an inflammation and pain response by the immune system (which is largely futile, since the white blood cells which get dispatched are not really up to the job of dissolving those crystals).]
Goutrin Ingredients:
Each veg. capsule contains:
200 mg Tart Cherry (Prunus cerasus - Fruit) (16:1, QCE 3200 mg Dry)
300 mg Curcumin (Curcuma longa - Rhizome)
50 mg Celery Seed (Apium graveolens - Seed) (16:1, QCE 800 mg Dry)
50 mg Devil's-claw (Harpagophytum procumbens - Secondary root tuber) (16:1, QCE 800 mg Dry)
50 mg Vitamin C (Ascorbic acid)
29 mg Fruit Bromelain (Ananas comosus var. comosus - Fruit) (1,800,000 FCC PU)
Non-medicinal ingredients: Hypromellose (Capsule shell).
Contains no Eggs, Wheat, Soy, Gluten, Corn, Dairy, Tree Nuts, or Peanuts.
Suggested Usage:
Adults: Take 1 capsule 3 times per day, with food. Consult a healthcare practitioner for prolonged use.
Warnings:
Do not use Nutridom GOUTart if you are pregnant or breastfeeding or have a thyroid disorder like hypothyroidism and hyperthyroidism.
Consult a healthcare practitioner prior to use if you are taking antibiotics, anticoagulant agents, antiplatelet medication or blood thinners, or anti-inflammatory agents; or if you have gallstones, bile duct obstruction, stomach ulcers or excess stomach acid, gastrointestinal lesions/ulcers, inflammation of the kidneys, diabetes or a renal disorder; or if you will be having surgery.
Some people may experience gastrointestinal discomfort. Allergic reactions can occur in people allergic to plants of the Asteraceae/Compositae/Daisy family; discontinue use if hypersensitivity/allergy occurs.
Celery seed may increase UV light sensitivity; limit excess exposure to ultraviolet rays while using.
Health Canada Natural Product Number: 80122879.
Supporting Science:
Regarding Tart Cherry:
Chen, Pei-En et al. “Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review.” Evidence-Based Complementary and Alternative Medicine: eCAM, 2019.
Schlesinger, Naomi et al. “Components of tart cherry juice inhibit NFκB activation and inflammation in acute gout.” Clinical and Experimental Rheumatology, 2022.
Regarding Curcumin:
Chen, Baofeng et al. “Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage.” Arthritis Research & Therapy, 2019.
Li, Xiong et al. “Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling.” Journal of Cellular Biochemistry, 2019.
Regarding Celery Seed:
Dolati, Karim et al. “Inhibitory Effects of Apium graveolens on Xanthine Oxidase Activity and Serum Uric Acid Levels in Hyperuricemic Mice.” Preventive Nutrition and Food Science, 2018.
Hang, Nguyen Thu et al. “Investigation of the mechanism of action of chemical constituents of celery seed against gout disease using network pharmacology, molecular docking, and molecular dynamics simulations.” Journal of Biomolecular Structure & Dynamics, 2024.
Soliman, Mohamed Mohamed et al. “Molecular and Histopathological Study on the Ameliorative Impacts of Petroselinum Crispum and Apium Graveolens against Experimental Hyperuricemia.” Scientific Reports, 2020.
Regarding Devil's Claw:
Fu, Qiong et al. “Uric acid-lowering effect of harpagoside and its protective effect against hyperuricemia-induced renal injury in mice.” Biochemical and Biophysical Research Communications, 2024.
Kondamudi, Narasimharao et al. “Harpagoside Content in Devil's Claw Extracts.” Natural Product Communications, 2016.
Regarding the Urate-Lowering Effects of Vitamin C:
Brzezińska, Olga et al. “Role of Vitamin C in Prophylaxis and Treatment of Gout-A Literature Review.” Nutrients, 2021.
Juraschek, Stephen P et al. “Effects of vitamin C supplementation on gout risk: results from the Physicians' Health Study II trial.” The American Journal of Clinical Nutrition, 2022.
Regarding the Anti-Inflammatory and Anti-Edema Effects of Bromelain:
Maisto, Maria et al. “Efficacy of a Multicomponent Nutraceutical Formulation for the Prevention and Treatment of Urinary Tract Stones.” International Journal of Molecular Sciences, 2023.
Chakraborty, Arka Jyoti et al. “Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective.” Life (Basel, Switzerland), 2021.
Regarding a Combination of Bromelain, Curcumin, and Devil's Claw:
Brochard, Sybille et al. “The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells.” BMC Complementary Medicine and Therapies, 2021.
Vaidya, Binit et al. “Synovial fluid uric acid level aids diagnosis of gout.” Biomedical reports, 2018.